Die Diagnose der Amyotrophen Lateralsklerose ist weiterhin eine Herausforderung.
Sowohl die revidierten El-Escorial-Kriterien als auch die Awaji-Kriterien werden
zum Teil in der klinischen Praxis genutzt, sind jedoch komplex und wenig
sensitiv. Die neu vorgeschlagenen Gold-Coast-Kriterien stellen eine
Erleichterung im klinischen Alltag dar. Eine Veranschaulichung der
Diagnosefindung nach den verschiedenen Kriterien findet sich in dem
Fallbeispiel.
The diagnosis of amyotrophic lateral sclerosis (ALS) is still challenging for
clinicians. In the absence of a reliable biomarker, the clinical and
electromyographic examination is of major importance to diagnose ALS. Mainly
developed for clinical trials, the well-established revised El-Escorial criteria
and Awaji criteria are sometimes also used in clinical routine. However, both
diagnostic criteria are complex and disconcerting especially for patients
because of various categories like “possible ALS” and
“probable ALS”. Additionally, a definite diagnosis can only be
made late in the course of the disease, or even sometimes it is not possible to
fulfill the diagnostic criteria. The newly proposed Gold Coast criteria are a
simplified synopsis of the previous diagnostic criteria. The combination of
progressive symptoms, clinical or electromyographic evidence of lower and upper
motor neuron dysfunction or progressive lower motor neuron dysfunction, and the
exclusion of other diseases lead to the diagnosis of ALS.
Schlüsselwörter
Amyotrophe Lateralsklerose - El-Escorial-Kriterien - Awaji-Kriterien - Gold-Coast-Kriterien
Key word
amyotrophic lateral sclerosis - El Escorial criteria - Awaji criteria - Gold Coast
Criteria
